What does VDR mean in Unclassified?
This page is about the meanings of the acronym/abbreviation/shorthand VDR in the Miscellaneous field in general and in the Unclassified terminology in particular.
Vitamin D Receptor
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Definition
What does VDR mean?
- Vitamin D receptor
- The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2vitamin D3) binds to VDR, which then forms a heterodimer with the retinoid-X receptor. The VDR heterodimer then enters the nucleus and binds to Vitamin D responsive elements (VDRE) in genomic DNA. VDR binding results in expression or transrepression of many specific gene products. VDR is also involved in microRNA-directed post transcriptional mechanisms. In humans, the vitamin D receptor is encoded by the VDR gene located on chromosome 12q13.11.VDR is expressed in most tissues of the body, and regulates transcription of genes involved in intestinal and renal transport of calcium and other minerals. Glucocorticoids decrease VDR expression. Many types of immune cells also express VDR.
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"VDR." Abbreviations.com. STANDS4 LLC, 2024. Web. 13 Jun 2024. <https://www.abbreviations.com/term/1465675>.
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